Based on the daily maximum power load values in Jingzhou, Jingmen, Yichang, Xianning and Suizhou areas of Hubei Province from 2008 to 2019 and the meteorological data of national meteorological observation stations in the same period, the relationships between the change rate of maximum meteorological load (L_pm), four comfort indexes such as temperature and humidity index (I), meteorological sensitive load index (MSLI), human comfort (ET) and somatosensory temperature index (Te) and temperature were analyzed. The daily maximum power load forecasting models were established based on the above four comfort indexes by using multiple regression and BP neural network method. The results show that the L_pm was positively correlated with temperature and the above four comfort indexes in summer, negatively correlated in winter, and the correlation was significantly higher in summer than in winter. The changes of the above four comfort indexes integrating temperature, humidity and wind speed could cause the change of the L_pm, and this change was more obvious in summer, especially in July and August. The errors of BP neural network model and multiple regression model were basically controlled within the requirements of the power department. The prediction effect of BP neural network was better than that of multiple regression. In the later business application, it was suggested to select ET index in Jingmen and Xianning, and four indexes in other cities can be used.